Over 44.5 in Chargers-Rams starts with Matthew Stafford against a defense allowing 7.6 yards per pass attempt through six games.
The Rams scored 35 points at Las Vegas last week, with Stafford throwing 3 touchdowns. Kyren Williams and Blake Corum supplied 192 rushing yards on 33 carries.
Justin Herbert's opportunity comes against a Rams pass rush with 10 sacks through seven games. Myles Garrett remains on injured reserve, and his practice window won't open this week.
Ladd McConkey is projected to start after practicing fully Wednesday following his concussion.