Stanford has allowed 5.3 yards per carry and 22 rushing touchdowns through eight games. Louisville brings a ground game averaging 215.0 yards and 5.9 per carry through seven.
Lincoln Kienholz has 10 rushing touchdowns to go with 10 passing scores.
Louisville -22.5 is a bet on that rushing advantage producing touchdowns. Louisville has scored touchdowns on 18 of 25 red-zone trips, while Stanford has allowed 27 on 31.
Stanford has scored 7 points at Duke, 3 at Wake Forest and 7 at Notre Dame in its three road games this season.