Notre Dame forced 20 turnovers against Villanova in its opener. Mercyhurst now brings a rebuilt offense to South Bend after scoring 43 points at Marquette.
The Lakers shot 29.3% from the field and 14.8% from three in that loss. Notre Dame's pressure could end Mercyhurst possessions before a shot, favoring Under 140.5 for Mercyhurst at Notre Dame.
Mercyhurst returned five players accounting for 25.7% of last season's scoring and 22.2% of its minutes. Tennessee Rainwater is also injured and out until at least mid-December.