Notre Dame forced 20 Villanova turnovers in Sunday's opener and scored 20 points off them. Mercyhurst committed 17 turnovers in Monday's 78-43 loss at Marquette.
Notre Dame -21 is a bet on taking shots away from Mercyhurst and getting extra attempts at the other end. The Irish collected 17 offensive rebounds against Villanova, while the Lakers gave up 20 offensive rebounds at Marquette.
Notre Dame turned those boards into 16 second-chance points.