Wizards +10.5 is a bet on Washington's scoring inside and Cleveland's trouble protecting leads.
The Wizards scored 62 paint points in Chicago and 56 in Charlotte, their first two road games. Anthony Davis scored 29 points in Charlotte, while Trae Young added 22 points and 10 assists.
Cleveland allowed Minnesota 58 paint points in Monday's overtime game.
The Cavaliers have committed 56 turnovers across their first three games. They lost after leading Philadelphia by 29 and beat Brooklyn by just 4 after leading by 22.