Joel Embiid and VJ Edgecombe are projected to play for the 76ers against the Pistons after missing the first meeting. Detroit is still without Jalen Duren.
Philadelphia scored 62 points in the paint against Chicago on Monday. With Embiid now facing a frontcourt missing Duren, interior scoring is the strongest reason for Over 219.
The 76ers also grabbed 13 offensive rebounds against Chicago. Detroit allowed 18 to Charlotte that same night.
Duncan Robinson has made at least 5 threes in 4 games for Detroit this season, including 6 of 9 on Monday.